The go-to pharmacology reference that medical and health science professionals have relied upon for more than 50 years! For more than 50 years, Goodman & Gilman's The Pharmacological Basis of Therapeutics, has been the comprehensive, go-to reference that medical and health science professionals have relied upon as the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman's balance of basic science and clinical applications has guided thousands of health care practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing and treating disease. The fourteenth edition features more than 600 color illustrations, including 50 new figures on mechanism of drug actions which emphasizes the link between basic mechanisms of action of drug action, pathophysiology of disease, and therapeutic use of drugs. Features: * Five NEW chapters: Pharmacovigilance Gastrointestinal Microbiome and Drug Response The Blood-Brain Barrier Cannabis Antibodies, Immune Checkpoint Inhibitors, CAR-T cells, and other Biological Agents * 600+ color illustrations * 50 NEW figures on mechanism of drug actions * All chapters have been revised and generally expanded with new material * Throughout: Expanded coverage of the need to consider genetic polymorphisms in designing appropriate therapies * A greatly revised and expanded chapter on Pharmacodynamics and the Molecular Mechanisms of Drug Action * 53 NEW contributors * NEW online updates